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Application procedure for the local hemostatic agent “GEMOVIS”

Preparation for use:
1
Along the perforation lines, open the GEMOVIS package and remove the corrugated bottle and the tip–applicator.
2
Vigorously knead or shake the bottle.
3
Remove the protective cap from the bottle.
4
Attach / screw the tip–applicator onto the neck of the bottle.

The hemostatic gel is ready for use.

Application:
1
Holding the bottle in the palm of the hand with fingers at the neck, bring the edge of the applicator tip as close as possible to the source(s) of bleeding.
2
Squeeze the bottom of the bottle to expel the required amount of gel into the area of the wound source.
3
After the entire wound cavity is filled with gel, it is tightly tamponaded. *
!
If necessary (in case of observed residual bleeding), repeat these actions.

The amount of hemostatic gel GEMOVIS used is determined by the type and nature of the bleeding and the depth of the wound.

Wound tamponade algorithm:
!
After introducing the hemostatic gel into the wound area, direct pressure on the wound MUST be applied. In most cases with deep bleeding, maintaining adequate direct pressure stops the bleeding within 60–70 seconds.
!
For complex injuries, including those in transitional zones, to stop bleeding after gel application, TIGHT tamponade of the wound MUST be used. In this case, tight tamponade can stop massive external bleeding from almost any wound.
The principle of tamponade is the same as that of a pressure dressing. Tamponade is performed using clean cloth, bandages, or a bandage impregnated with GEMOVIS hemostatic gel.
Its main purpose is to completely or as fully as possible fill the wound area with gel, so that it can interact with the wound surface and bleeding vessels and prevent the blood flow from washing the gel away from the bleeding source.
After introducing the gel into the wound, the wound should be tightly packed with a bandage.

This action promotes adhesion of the gel to the bleeding areas of the wound, thereby initiating the hemostatic reaction of the gel components to stop bleeding. It is critically important to insert the gel mass or a gel‑impregnated bandage as deeply as possible into the wound to achieve direct contact of the gel with the bleeding vessels. This is how GEMOVIS acts directly on the bleeding source and triggers the hemostatic cascade.
A pressure tamponade lasting 60–70 seconds, performed by applying maximum possible pressure to the bleeding vessel, leads to successful hemostasis in the wound. The combined action of the hemostatic components of the gel with simultaneous pressure on the wound area and on the bleeding surfaces/vessels is a key condition for stopping the bleeding.

Maintaining pressure on the wound for 60–70 seconds will support the formation of hemostasis. Inadequate, too‑light pressure can interfere with bleeding control: if the pressure is too weak, the gel will not interact properly with the blood, and bleeding will continue to seep.

Figure 1

Figure 1 shows an example of an INADEQUATE pressure tamponade algorithm for achieving hemostasis in the wound.

Figure 2

Figure 2 shows an example of an ADEQUATE pressure tamponade algorithm for achieving hemostasis in the wound.

Fixation with a pressure bandage.
After 1.5–2 minutes (following visual confirmation of complete hemostasis and no recurrent bleeding), secure the wound with a firm pressure bandage. If possible, immobilize the affected area.
Important clarifications.
For deep and complex (lacerated) wound sites it is recommended:
1
The hemostatic gel should be delivered as close as possible to the source of bleeding, either by a) direct application using the dispenser–applicator, or by b) introducing a fabric‑based material suitable for tamponade and impregnated with the gel.
2
After introducing the local hemostatic agent GEMOVIS into the wound (Method 1 or Method 2), firm pressure MUST be applied to the tamponating material over the wound area for 60–70 seconds (Figure 2). This will promote faster formation of a blood clot and help achieve hemostasis in the wound.
3
Side effects: After introducing the local hemostatic agent GEMOVIS into the wound area, a brief sensation of burning may be felt at the site of application.